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Shu Lam: We've developed a new class of antimicrobial agents, which are very unique. They come in the form of tiny star-shaped molecules that are made from short chains of proteins. We found that they are very effective at wiping out [bacterial] infections in mice and they are also relatively non-toxic to the body.And how do you kill bacteria with star-shaped molecules?
One of the ways is that the molecule sticks into the surface of the bacteria and rips apart the bacterial cell wall. Once their membrane is destroyed the bacteria dies.So you're basically jabbing bacteria with molecular ninja stars?
Sort of. These star polymers screw up the way bacteria survives. Bacteria need to divide and grow but when our star is attached to the membrane it interferes with these processes. This puts a lot of stress on the bacteria and it initiates a process to kill itself from stress.
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For our star molecule, each arm is actually a chain of protein units, and each of these arms are referred to as a polymer. Each polymer is connected at the core. They consist of small chains of proteins, which are essentially called peptides, this is why we call them "peptide polymers." We make them through a method calledpolymerisation. It's basically like playing with Lego… you have small building blocks which you assemble together, you link all of the protein units together to make a long chain, and this chain is called a polymer.What led your team to start researching these star-shaped polymers?
The expertise in our lab lies in chemistry, and we know chemistry can make cool and useful materials. So we've been working on using polymers to solve problems in healthcare. We have always wanted to develop something that would be useful in overcoming bacterial infections.Could peptide polymers be used to fight any other diseases or infections?
Currently we are [only] looking at bacterial infections. Our results have shown that we can kill one group of bacteria, but there are many different kinds of bacteria. So we are looking at whether we can expand our system and look at killing all kinds of bacteria.If more research proves successful, how long until doctors are able to prescribe this sort of medication?
This is quite difficult to answer. We are still quite far from there because we still need to do a lot of studies and a lot of tests—for example, to see whether these polymers have any side effects on our bodies. We need a lot of detailed assessments like that, [but] it they could hopefully be implemented in the near future.So if this star polymer treatment was available in the future, what would it look like?
The quickest way to make this available to the public is through topical application, simply because you go through less procedures as opposed to ingesting these molecules into the body. So when you have a wound or a bacterial infection on the wound then you [generally] apply some sort of antibacterial cream.The star polymers could potentially become one of the anti-bacterial ingredients in this cream. Ultimately, we hope that what we're discovering here could replace antibiotics. In other words, we also hope that we will be able to inject this into the body to treat serious infections, or even to disperse it in the form of a pill which patients can take, just like somebody would take an antibiotic.Follow Vince on Twitter