It had humble beginnings, but the formerly legal high is now a runaway threat wreaking havoc on Britain's streets and prisons.
The government has described the synthetic weed Spice as "the most serious threat to the safety and security of the prison system," and it's not wrong.
As of today, legal highs are no longer legal in the UK. We spent the night with some salesmen and users to get their take on what comes next.
An interview with the man who owned the UK's biggest legal high wholesale business.
Days after a study suggested synthetic cannabis can be as physically addictive as heroin, we met some users who are stuck in the throes of addiction.
Meet Karl Williams, a Londoner whose Dubai holiday basically went up in flames when he and his friends were arrested on drug charges in 2013.
According to the chief inspector of prisons, spice is having a "devastating impact" on inmates, so we asked them to tell us what they've seen.
Amid more setbacks to the Psychoactive Substances Act, it's becoming clearer and clearer that the British government cannot grasp how to deal with drugs.
While there has been a national ban on synthetic cannabis since 2012, some states are cracking down more than others.
Two case studies in different areas of the UK demonstrate that a blanket ban on all psychoactive substances isn't going to have nearly the kind of effect the Home Office believes it will.
I started smoking synthetic cannabis after the real stuff stopped doing it for me. Four years later, I'm suffering from a weird, white blood cell-related illness supposedly triggered by certain cannabinoids.