In 2010 it was the UK's fourth favourite substance; nowadays it's used almost exclusively on the chemsex scene.
When the tabloids write horror stories about drugs such as mephedrone or laughing gas, searches for how to buy those drugs go through the roof.
What, exactly, is so wrong with getting high in 2016?
As of today, legal highs are no longer legal in the UK. We spent the night with some salesmen and users to get their take on what comes next.
An interview with the man who owned the UK's biggest legal high wholesale business.
While there has been a national ban on synthetic cannabis since 2012, some states are cracking down more than others.
If we don't rapidly move toward marijuana legalisation, a similar catastrophe could affect teens or young adults here.
While the government drew up new counterproductive drug legislation, police officers around Britain took it upon themselves to react against the war on drugs.
Demonstrators gathered in Parliament Square to inhale NOS in protest against the UK government's new Psychoactive Substances Bill, which bans basically anything that'll get you high.