The single, the first from Del Rey's as-yet-untitled sixth LP, premiered on Annie Mac's BBC Radio 1 show.
In new interviews with BBC Radio 1 and the Guardian, Monáe confirmed the late icon's involvement.
She also performed acoustic versions of "Los Ageless" and "New York" on Annie Mac's show.
It's the UK producer's first official solo single since 2013.
Guys, '22 A Million' is gonna be so good.
Listen to the French duo's latest track "Randy" via the BBC.
The UK singer performed songs from her Oneohtrix Point Never and Hudson Mohawke-produced album 'HOPELESSNESS.'
"Yo Ikea, allow Kanye to create!"
"Safe and Sound" will debut on Annie Mac's BBC Radio 1 show this afternoon.
The track comes ahead of her highly anticipated debut album 'Nothing’s Real.'
Blake made the announcement on DJ Annie Mac BBC 1 radio show.
Listen to "Radio Silence" and "I Need a Forest Fire," featuring Bon Iver.