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Watch the Trailer for Tonight's 'VICE' on HBO Special Report on the Fight to End AIDS

From high-tech American labs to South African clinics, the special report goes inside the search for the cure and a preventative vaccine that could lead to the first AIDS-free generation in decades.

UPDATE 12/1/15: Today is World AIDS Day, and we will be premiering our new special report, Countdown to Zero, this evening on HBO. Watch the trailer above, and don't miss the special report when it becomes available on HBO Now and HBO Go tonight.

Countdown to Zero is an upcoming VICE special report on the fight to end AIDS. Focusing on the breakthroughs in prevention and treatment, the documentary will air on HBO tonight, December 1, World AIDS Day.

The special, hosted by VICE founders and correspondents Shane Smith and Suroosh Alvi, goes inside the search for a cure and preventative vaccine that could bring about the first AIDS-free generation in decades. From the high-tech American labs, to the South African clinics participating in the largest vaccine trial in history, VICE sits down with patients, policymakers, activists, and researchers leading the international charge for an AIDS-free world.

In addition to medical researchers, Smith sits down with President George W. Bush at the Bush Institute on SMU's campus in Dallas to discuss the success of the United States-led PEPFAR (President's Emergency Plan for AIDS Relief) initiative. And Alvi travels to Rwanda with Bono, the lead singer of U2 and co-founder of (RED) and ONE, to see PEPFAR in action.

"HIV is the epidemic of our modern age. We're on the brink of scientific developments that will end the disease for good—but it isn't gone yet," says Smith. "Millions are still being infected every year. This documentary is a comprehensive look at the state of HIV/AIDS today, how far we've come in fighting it, and how far we still have to go."