The nation is the third country to perform a lunar sample return mission, after the delivery of Moon material to Mongolia on Wednesday.
Photos show the nation's flag on the moon, 51 years after the US left theirs.
The mission’s ascent vehicle has left the Moon, carrying its valuable cargo of lunar rocks, and is headed for a rendezvous and pass-off in lunar orbit.
The mission will return samples of moon rocks to Earth for the first time since the 1970s.
Chang’e-5 is tasked with collecting lunar samples and bringing them back to Earth next month.
The moon is harboring billions of dollars' worth of Helium-3, a critical component for nuclear fusion. India’s space agency wants to be the first to mine it.